| 津血源颗粒上调干燥综合征模型鼠唾液腺水通道蛋白5表达的实验研究 |
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| 引用本文： | 钱先,王剑蓉,汪红仪,许超. 津血源颗粒上调干燥综合征模型鼠唾液腺水通道蛋白5表达的实验研究[J]. 中华中医药杂志, 2011, 0(10): 2375-2377 |
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| 作者姓名： | 钱先 王剑蓉 汪红仪 许超 |
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| 作者单位： | 江苏省中医院;南京医科大学;南京中医药大学; |
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| 基金项目： | 江苏省自然科学基金(No.BK2007176)~~ |
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| 摘 要： | 目的:探讨津血源颗粒对干燥综合征(SS)模型大鼠唾液腺中水通道蛋白5(AQP5)表达的影响。方法:用免疫组化法分析SS大鼠唾液腺AQP5表达特点。结果:正常组细胞膜上存在较多AQP5蛋白;佐剂组细胞膜上有表达,但数量较正常组明显减少;模型组腺泡萎缩,残存腺泡顶膜表达明显减少甚至消失,与正常组比较,有显著性差异;津血源颗粒组大部分细胞膜有AQP5蛋白表达,较模型组表达数量明显增多,且分布均匀。结论:津血源颗粒可明显增强SS模型鼠唾液腺中AQP5的表达。
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| 关 键 词： | 津血源颗粒 干燥综合征模型鼠 唾液腺AQP5表达 |
Study of AQP5 expression up-regulation in salivary gland of SS rats by Jinxueyuan Granula |
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| QIAN Xian,WANG Jian-rong,WANG Hong-yi,XU Chao. Study of AQP5 expression up-regulation in salivary gland of SS rats by Jinxueyuan Granula[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(10): 2375-2377 |
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| Authors: | QIAN Xian WANG Jian-rong WANG Hong-yi XU Chao |
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| Affiliation: | QIAN Xian1,WANG Jian-rong1,WANG Hong-yi2,XU Chao3(1Jiangsu Provincial Hospital of TCM,Nanjing 210029,China,2Nanjing Medical University,3Nanjing University of Chinese Medicine,China) |
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| Abstract: | Objective: To investigate the influence of Jinxueyuan Granula on the expression of Aquaporin 5(AQP5) in the salivary gland of Sjogren's syndrome(SS) rats.Methods: Analysis of the characteristic of AQP5 expression in the salivary gland of SS rats by immunohistochemistry.Results: There were more AQP5 expression in the membranes of rats in normal group;The AQP5 also expressed on membranes of rats in adjuvant group,but the amount was significantly reduced compared with the normal group.The acinus was atrophy an... |
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| Keywords: | Jinxueyuan Granula Sjogren s syndrome(SS) rats Expression of AQP5 in the salivary gland |
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