| 五倍子与黄柏外用治疗急性湿疹的配伍合理性研究 |
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| 引用本文： | 林清,张建军,李伟,郭青云,王淳,陈振振,王丽丽,高学敏. 五倍子与黄柏外用治疗急性湿疹的配伍合理性研究[J]. 中华中医药杂志, 2011, 0(9): 2126-2129 |
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| 作者姓名： | 林清 张建军 李伟 郭青云 王淳 陈振振 王丽丽 高学敏 |
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| 作者单位： | 北京中医药大学基础医学院;解放军309医院; |
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| 摘 要： | 目的:探讨中药五倍子与黄柏配伍治疗急性湿疹的合理性,为其外治法临床应用提供依据。方法:通过对二甲苯诱发的小鼠耳廓肿胀的急性炎症实验、2、4-二硝基氯苯(DNCB)诱发的小鼠迟发型超敏反应实验和体外抑菌试验,考察配伍前后的作用。结果:五倍子组和黄柏组能明显减轻二甲苯所致小鼠的耳肿胀度,与对照组比较有显著性差异(P<0.01),而黄柏五倍子组与对照组比较无统计学意义;黄柏组能降低迟发型超敏反应值,与对照组比较有显著性差异(P<0.05),黄柏五倍子组与对照组比较无统计学意义;随着药物浓度的降低,黄柏五倍子组对体外细菌的抑制作用明显弱于五倍子组。结论:五倍子与黄柏配伍治疗急性湿疹使药效降低,为不合理配伍,即中医配伍中的"相恶"。
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| 关 键 词： | 五倍子 黄柏 配伍 急性湿疹 |
Rational studies of Galla Chinensis and Phellodendri Chinensis Cortex on treating acute eczema |
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| LIN Qing,ZHANG Jian-jun,LI Wei,GUO Qing-yun,WANG Chun,CHEN Zhen-zhen,WANG Li-li,GAO Xue-min. Rational studies of Galla Chinensis and Phellodendri Chinensis Cortex on treating acute eczema[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(9): 2126-2129 |
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| Authors: | LIN Qing ZHANG Jian-jun LI Wei GUO Qing-yun WANG Chun CHEN Zhen-zhen WANG Li-li GAO Xue-min |
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| Affiliation: | LIN Qing1,ZHANG Jian-jun1,LI Wei1,GUO Qing-yun2,WANG Chun1,CHEN Zhen-zhen1,WANG Li-li1,GAO Xue-min1(1Basic Medical School,Beijing University of Chinese Medicine,Beijing 100029,China,2The 309 Hospital of PLA,Beijing 100091,China) |
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| Abstract: | Objective: To explore the compatible application rationality of Wubeizi(Galla Chinensis) and Huangbai(Phellodendri Chinensis Cortex) on treating acute eczema to provide the basic for clinic application.Methods: To observe and evaluate the effects of different groups on mouse xylene-induced ear tumefaction,DNCB-induced allergic reaction and the microbial activity in vitro.Results: Wubeizi group and Huangbai group both can lessen the ear swelling of mice(P<0.01),while Huangbai-wubeizi group did not have a sig... |
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| Keywords: | Galla Chinensis Phellodendri Chinensis Cortex Compatibility Acute eczema |
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