| 钝顶螺旋藻多糖对白血病患者外周血LAK细胞活性的影响 |
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| 引用本文： | 曾波航,王光明,曾亚仑.钝顶螺旋藻多糖对白血病患者外周血LAK细胞活性的影响[J].中国海洋药物,2000,19(2):39-41. |
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| 作者姓名： | 曾波航 王光明 曾亚仑 |
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| 作者单位： | 1. 广州医学院第二附属医院肿瘤科,510260
2. 广州白云山中药厂,广州,510515 |
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| 摘 要： | 目的 了解纯顶螺旋藻多糖（ＳＰＰ）对正常人和白血病患者ＬＡＫ细胞活性作用，探讨螺旋藻作用机理。方法 以 Ｒａｊｉ细胞（人Ｂ细胞白血病细胞株）为靶细胞，用＾３Ｈ－ＴｄＲ渗入法检测ＬＡＫ细胞活性。结果 白血病病人ＬＡＫ细胞活性降低；ＳＰＰ可增强正常人和病人ＬＡＫ细胞活性，且对正常人ＬＡＫ细胞活性增强作用大于病人。结论 ＳＰＰ可刺激ＬＡＫ细胞活性，减少ｒＩＬ－２用量。
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| 关 键 词： | 纯顶螺旋藻多糖 LAK细胞 白血病 药物疗法 |
EFFECT OF SPIRULINA PATENSIS POLYSACCHARIDE ON THE ACTIBITIES OF LAK CELL OF PERIPHERAL BLOOD MONONUCLEAR CELL IN PATIENTS WITH LEUKEMIA |
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| Zeng Bohang,Wang Guangming,Zeng Yalun.EFFECT OF SPIRULINA PATENSIS POLYSACCHARIDE ON THE ACTIBITIES OF LAK CELL OF PERIPHERAL BLOOD MONONUCLEAR CELL IN PATIENTS WITH LEUKEMIA[J].Chinese Journal of Marine Drugs,2000,19(2):39-41. |
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| Authors: | Zeng Bohang Wang Guangming Zeng Yalun |
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| Abstract: | Objective: The effects of spirulina patensis polysaccharide (SPP)on the activities of lymphokine-activited killer (LAK ) cell from normal individuals and patients with leukemia were comparized. Mechanism of SPP'S immunological effection was studied. Methods: With Raji cells being target cell,LAK cell activity was determined by 3H-TdR release assay' Results:LAK cell activity was lower in patients with leukemia than in normaI individuals. SPP could increase LAK cell activity both normal individuals and patients with leukemia. It was higher LAK cell activity after adding SPP in normal individuals than patients with leukemia. Conclusion: SPP is able to stimulate LAK cell activity and to decrease rIL-2 quantity in LAK cell activation. |
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| Keywords: | Polysaccaried of spirulina platensis (SPP) LAK cell Leukemia |
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