胃癌胃异常增生组织中CD44V6表达及其意义

目的探讨转移相关基因CD44V6与正常胃粘膜、胃异常增生组织及胃癌组织中某些生物学行为的关系.方法采用免疫组化SP法,检测正常胃粘膜30例、胃异常增生粘膜组织30例、胃癌原发灶84例CD44V6的表达.结果 CD44V6在正常胃粘膜呈阴性表达;胃异常增生粘膜组织、胃癌组织呈阳性表达,其中异常增生20.00%,胃癌中肠型胃癌(71.43%)明显高于弥漫型胃癌(37.14%)(P＜0.05);淋巴结转移组(87.87%)明显高于无淋巴结转移(38.77%)(P＜0.05);CD44V6阳性率与肿瘤大小无关(P＞0.05);不同胃癌病理分型中淋巴结CD44V6阳性率差异无显著意义(P＞0.05).结论 CD44V6阳性表达同胃癌生物学行为密切相关,是预测侵袭与转移有价值的指标.

Expression of CD44V6 and its significance in gastric epithelial dysplasia and gastric carcinoma

Objective To study the expression of CD44V 6 and its significance in normal gastric mucosa tissues,gastric epithelial dysplasia and gastric adenocarcinoma.Methods Immunohistochemical method was used to detect CD44V 6 in 30 cases of normal gastric mucosa tissues,30 cases of epithelial dysplasia and 84 cases of gastric adenocarcinoma.Results CD44V 6 didn't express in normal gastric mucosa tissues.The positive expression rate of CD44V 6 in gastric epithelial dysplasia was 20.00%.CD44V 6 expression was found in 35 cases(71.43%) of intestine-type cancers while 13 cases(37.14%) in diffuse type cancers.The CD44V 6 expressed in 29 cases with lymph node involvement(87.87%) which was significantly higher than that without metastasis(38.77%).There was no association between CD44V 6 expression and tumor size.Conclusion CD44V 6 might be a valuable marker in assessing biological behavior,invasion and metastatic potential of gastric carcinoma.