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某县柯尔克孜族健康人群胃蛋白酶原参考范围的建立
引用本文:王亚鹏,王涛,任预应,陈万瑛,李向东,刘宗良,张珏,黄飚,范俊,陈道桢.某县柯尔克孜族健康人群胃蛋白酶原参考范围的建立[J].检验医学与临床,2014,0(12):1615-1617.
作者姓名:王亚鹏  王涛  任预应  陈万瑛  李向东  刘宗良  张珏  黄飚  范俊  陈道桢
作者单位:王亚鹏(新疆维吾尔自治区阿合奇县人民医院检验科 843500);王涛(新疆维吾尔自治区阿合奇县人民医院检验科 843500);任预应(新疆维吾尔自治区阿合奇县人民医院检验科 843500);陈万瑛(新疆维吾尔自治区阿合奇县人民医院检验科 843500);李向东(新疆维吾尔自治区阿合奇县人民医院检验科 843500); 刘宗良 (江苏省无锡市第三人民医院消化内科 214000); 张珏 (江苏省原子医学研究所药物研发中心,江苏无锡,214063); 黄飚 (江苏省原子医学研究所药物研发中心,江苏无锡,214063); 范俊 (江苏省原子医学研究所药物研发中心,江苏无锡,214063); 陈道桢 (新疆维吾尔自治区阿合奇县人民医院检验科 843500 南京医科大学附属无锡妇幼保健院中心实验室,江苏无锡 214002);
基金项目:新疆维吾尔自治区科技支疆项目计划(2013911120)
摘    要:目的建立新疆阿合奇地区柯尔克孜族健康人群胃蛋白酶原参考范围。方法采用时间分辨荧光免疫分析法对792例健康人群血清中胃蛋白酶原PGⅠ和PGⅡ的含量进行测定,并计算PGⅠ/Ⅱ值。结果 792例健康者血清中的PGⅠ、PGⅡ和PGⅠ/Ⅱ值均呈明显偏态分布。血清中PG含量与年龄无相关性,PGⅠ和PGⅠ/Ⅱ与性别显著相关,但PGⅡ与性别无相关性。血清中PGⅠ、PGⅡ和PGⅠ/Ⅱ的参考范围分别为34.06∽301.24μg/L、小于或等于28.35μg/L、大于或等于3.30。结论采用时间分辨荧光免疫分析法,建立适合该地区健康人群血清中胃蛋白酶原参考范围,有利于提高对胃相关疾病的阳性检出率,促进胃蛋白酶原血清学检测在该地区的发展。

关 键 词:胃蛋白酶原  参考范围  柯尔克孜族

Establishment of the reference range of pepsinogen in healthy population of Kirgiz tribe in Aheqi county of Xinjiang
Institution:5 WANG Ya-peng, WANG Tao, REN Yu-ying, CHEN Wan-ying, LI Xiang-dong, LIU Zong-liang, ZHANG Jue, HUA NG Biao, FAN Jun, CHEN Dao-zhen (1. The People's Hospital of Aheqi County 843500,China 2. Wuxi No. 3 People's Hospital Xinjiang 214000,Chinas3. J iangsu Institute of nuclear medicine Wuxi , J iangsu 214063,China 4. Central Laboratory, Wuxi Hospital for Matemaland Child Health Care Affiliated Medical School of Nanjin ,Wuxi Jiangsu 214002,China)
Abstract:Objective To establish the reference range of pepsinogen in healthy population of Kirgiz tribe in Aheqi county of Xinjiang .Methods We detected the serum pepsinogen PG Ⅰ and PG Ⅱ levels by real-time fluorescence immunoassay in 792 cases of healthy population and calculated the values of PG Ⅰ /PG Ⅱ .Results The serum level of PG Ⅰ ,PG Ⅱ and the value of PG Ⅰ /PG Ⅱ showed a significantly skewed distribution in 792 cases of healthy population .The serum levels of PG had no significant correlation with age ,PG Ⅰ and PG Ⅰ / Ⅱ was significantly associated with gender ,but PG Ⅱ had no significant difference with gender .The reference ranges of serum PG Ⅰ ,PG Ⅱ and PG Ⅰ / Ⅱ were 34 .06 ~ 301 .24 μg/L ,≤ 28 .35 μg/L and ≥ 3 .30 respectively .Conclusion To establish the suitable reference range of pepsinogen by real-time fluorescence immunoassay in healthy population of this region will heip to improve the positive rate of stomach-related diseases ,and promote the development of pepsinogen serological test in this region .
Keywords:pepsinogen  reference range  Kirgiz tribe
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