氧气驱动雾化吸入盐酸布地奈德治疗急性喉炎的疗效及安全性研究

目的探讨氧气驱动雾化吸入盐酸布地奈德治疗小儿急性喉炎的疗效及安全性。方法将该院2012年9月至2013年4月收治的92例急性喉炎患儿按照1∶1比例随机分为观察组和对照组,每组各46例,2组均给予氧气驱动雾化吸入（3L/min）治疗,观察组同时加用氧气驱动雾化吸入盐酸布地奈德治疗,疗程结束后,对2组患儿的治疗效果及安全性进行统计学分析。结果观察组患儿临床各症状消失时间及住院时间均明显短于对照组,差异有统计学意义（P〈0.05）;对照组总有效率为71.74%,观察组总有效率为97.83%,差异有统计学意义（P〈0.05）;对照组总不良反应发生率为26.09%,观察组不良反应发生率为6.52%,差异有统计学意义（P〈0.05）。结论氧气驱动雾化吸入盐酸布地奈德治疗小儿急性喉炎疗效确切,可促进临床症状消除,患儿耐受性好,可作为急性喉炎的有效治疗药物。

Clinical observation efficacy and security of acute laryngitis treated by budesonide aerosol inhalation

Objective To study the efficacy and security of acute laryngitis treated by budesonide aerosol inha-lation .Methods 92 cases of children with acute laryngitis in our hospital were randomly divided into two groups ac-cording to the ratio of 1∶1 from September 2012 to April 2013 ,46 cases in each group .Two groups were given oxy-gen atomizing inhalation（3 L/min） treatment ,and the observation group at the same time was treated with budes-onide aerosol inhalation .After treatment the efficacy and security in two groups of children was statistical analyzed . Results In the observation group clinical symptoms disappear time and hospital stay were significantly shorter than the control group（P〈0 .05） ,and the control group total effective rate was 71 .74% ,yet the observation group total effective rate was 97 .83% .The total effective in the observation group was obviously higher than that of the control group（P〈0 .05） .In the control group the total incidence of adverse reactions was 26 .09% ,and in the observation group the total incidence of adverse reactions was 6 .52% ,the incidence of adverse reactions in observation group was obviously lower than the control group（P〈0 .05） .Conclusion Budesonide aerosol inhalation treating children with acute laryngitis posses good effect ,and promote the elimination of clinical symptoms in children with toleratance ,can be used as effective drug for largngitis .