四逆散合痛泻要方加味对肠易激综合征患者血清5-羟色胺表达水平的影响研究

目的 探讨四逆散合痛泻要方加味对肠易激综合征（IBS ）患者血清5-羟色胺（5-HT ）表达水平的影响。方法 选择2012年1月至2013年1月该院脾胃科诊治的60例腹泻型IBS患者为研究对象，并随机分为两组，对照组给予口服曲美布汀＋三联活菌，观察组给予四逆散合痛泻要方加味治疗，观察治疗前后主要症状积分及血清5-HT水平的变化。结果 治疗1个疗程后，两组患者腹痛、腹泻、腹胀、大便急迫、肛门坠胀等主要症状积分及5-HT水平均较治疗前有明显降低，差异有统计学意义（P＜0．05），且上述指标观察组明显低于对照组，差异有统计学意义（ P＜0．05）；观察组治疗总有效率为83．33％，明显高于对照组的60．00％，差异有统计学意义（ P＜0．05）。结论 四逆散合痛泻要方加味可以调节5-HT的分泌，改善胃肠道运动紊乱和肠道分泌异常情况。

Clinical research on effects of Sinisanhetong decoction on 5-HT in patients with irritable bowel syndrome

Objective To investigate effects of Sinisanhetong decoction on 5-HT in patients with irritable bowel syndrome （IBS ） .Methods Sixty cases of diarrhea-predominant IBS patients were randomly divided into two groups ,30 cases in each group ,all cases in the control group were treated with Trimebutine ＋ triple viable ,and those in the observation group treated with Sinisanhetong decoction ,the main symptom scores and serum 5-HT level changes were compared between the two groups before and after treatment .Results After one course of treatment ,the abdominal pain ,diarrhea ,bloating ,stool urgency ,anal and other major symptom scores and serum concentration of 5-HT in the two groups were significantly lower than those before treatment ,and those in the the observation group were lower than those in the control group ,the differences were statistically significant （P〈0 .05）;The total effective rate in the observation group was 83 .33% ,and it was significantly higher than the 60 .00% in the the control group , the difference was statistically significant （P〈0 .05） .Conclusion Sinisanhetong decoction can regulate the normal regulation of 5-HT secretion in patients with IBS ,and it can improve the gastrointestinal motility disorders and intestinal secretion abnormalities .