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Collagen fleece-bound fibrin sealant is not associated with an increased risk of thromboembolic events or major bleeding after its use for haemostasis in surgery: a prospective multicentre surveillance study
Authors:Mathias Birth  Joan Figueras  Stéphane Bernardini  Tine Troen  Klaus Günther  Darius Mirza  Frank Viborg Mortensen
Affiliation:1. Klinik für Allgemein-, Viszeral-, Thorax- und Gef?sschirurgie, HANSE-Klinikum Stralsund, Stralsund, Germany
2. Servicio de Cirugia General, Dr. Josep Trueta Hospital, IDiBGi, Girona, Spain
3. Service d'Urologie, CHU Saint Jacques, Besan?on, France
4. Biostatistics, Nycomed, Roskilde, Denmark
5. Abteilung für Allgemein- und Viszeralchirurgie, Klinik Hallerwiese, Nürnberg, Germany
6. The Liver Unit, Queen Elizabeth Hospital and Birmingham Children's Hospital, Birmingham, UK
7. Kirurgisk Gastroenterologisk Afdeling L, Aarhus University Hospital, NBG, Aarhus, Denmark
Abstract:

Background  

Topical haemostatic agents are used to help achieve haemostasis during surgery when standard surgical techniques are insufficient. The objective of this study was to confirm the safety profile of an equine collagen patch coated with human fibrinogen and human thrombin with particular focus on the occurrence of thromboembolic events (TEEs), major bleeding and immunological events.
Keywords:
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