帕罗西汀与阿米替林治疗躯体化障碍的疗效比较

目的比较帕罗西汀与阿米替林治疗躯体化障碍的疗效和不良反应。方法81例躯体化障碍患者随机分成2组,分别用帕罗西汀与阿米替林治疗8 wk。用症状自评量表(SCL-90)中的躯体化、抑郁和焦虑3个因子总分评定症状变化,用不同减分率评定疗效。用不良反应量表(TESS)评定药物不良反应。结果帕罗西汀组痊愈率为61.90%,总有效率为90.48%;阿米替林的痊愈率为43.59%,总有效率为71.79%,2组疗效比较差异有统计学意义(P<0.05)。2组TESS测评,各时点组间比较,差异有统计学或高度统计学意义(P<0.05或P<0.01)。结论帕罗西汀治疗躯体化障碍疗效确切,不良反应较小。

Comparison between paroxetine and amitriptyline in the treatment of somatization disorder

AIM To compare the therapeutic effects and adverse drug reactions between paroxetine and amitriptyline in the treatment of somatization disorder.METHODS Eighty-one patients with somatization disorder were randomized into 2 groups,which were treated with paroxetine or amitriptyline for 8 wk.The symptomatic changes were evaluated using the total score of somatization,depression,and anxiety as described in symptom chek-list 90(SCL-90),the therapeutic effect was assessed using various subtraction rates,and drug-related adverse drug reactions were evaluated using the treatment emergent symptom scale(TESS).RESULTS The recovery rate was 61.90% in the paroxetine treatment group and(43.59%) in the amitriptyline treatment group,and the total effective rate was 90.48% and 71.79%,respectively.The difference in the efficacy between 2 groups was significant(P<0.05).TESS tests revealed that there were significant differences between 2 groups at various time points.CONCLUSION Paroxetine is effective in the treatment of somatization disorders,but has few adverse drug reactions.