| 孕甾烷x受体在药物代谢中的作用及研究进展 |
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| 引用本文： | 张轶雯,鲍美华,周丽华,周宏灏. 孕甾烷x受体在药物代谢中的作用及研究进展[J]. 中国临床药理学与治疗学, 2013, 0(10): 1169-1174 |
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| 作者姓名： | 张轶雯 鲍美华 周丽华 周宏灏 |
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| 作者单位： | [1]中南大学临床药理研究所,湖南长沙410008 [2]长沙市中心医院呼吸内科,湖南长沙410004 |
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| 基金项目： | 重大新药创制专项临床前药物代谢动力学技术平台资助项目（20092X0950L032,2009ZX09304-003）;湖南省教育厅科学研究项目（11C0152） |
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| 摘 要： | 孕甾烷X受体（Pregnane X receptor，PXR）为核受体超家族中NRII亚家族成员，于肝脏和肠道中广泛表达。该受体作为药物代谢的关键调控因子广泛参与药物的吸收、分布、代谢及排泄过程。本文从药物代谢角度分别对PXR参与调节的Ⅰ、Ⅱ相代谢酶及转运体进行介绍，为临床药物相互作用及针对PXR为靶点的药物研发提供参考。
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| 关 键 词： | 孕甾烷X受体 药物代谢 调节 |
Function of pregnane X receptor in drug mechanism and research pro- gress |
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| ZHANG Yi-wen,BAO Mei-hua,ZHOU Li-hua,ZHOU Hong-hao. Function of pregnane X receptor in drug mechanism and research pro- gress[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 0(10): 1169-1174 |
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| Authors: | ZHANG Yi-wen BAO Mei-hua ZHOU Li-hua ZHOU Hong-hao |
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| Affiliation: | 1 Institute of Clinical Phormacology, Central South Vniversity, Changsha 410008, Hunan, China; e Department of Respiratory, ChangshaCenter Hospital, Changsha410004, Hunan, China |
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| Abstract: | ABSTRACT Pregnane X receptor （PXR） is a member of the nuclear receptor superfamily NRII subfamily, which is widely expressed in the liver and the intestine. The receptor as a key regulator of drug metabolism are widely involved in drug absorption, distribution, metabolism and excretion process. This review will introduce I , Ⅱphase metabolizing enzymes and trans-porters in the regulation of PXR. It will provide part of the basis for clinical drug interaction and drug research and development for PXR as a tar get. |
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| Keywords: | Pregnane X receptor Drug me-tabolism Regulation |
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