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Idiopathic thrombocytopenic purpura and myasthenia gravis after fludarabine treatment for chronic lymphocytic leukemia |
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| Authors: | Fujimaki Katsumichi Takasaki Hirotaka Koharazawa Hideyuki Takabayashi Maki Yamaji Satoshi Baba Yasuhisa Kanamori Heiwa Ishigatsubo Yoshiaki |
| Institution: | a First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan b Department of Neurology, Yokohama City University School of Medicine, Yokohama, Japan |
| Abstract: | We report a patient with chronic lymphocytic leukemia (CLL) who developed idiopathic thrombocytopenic purpura (ITP) and myasthenia gravis (MG) after fludarabine therapy. ITP developed after 6 cycles of fludarabine treatment, and MG occurred 2 months after the onset of ITP. MG was successfully treated with immunosuppressive therapy and plasma exchange, while rituximab was effective for CLL and ITP. Fludarabine seemed to have an important role in the onset of ITP and MG in this case. |
| Keywords: | Chronic lymphocytic leukemia fludarabine idiopathic thrombocytopenic purpura myasthenia gravis rituximab |
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