|
|||||
|
|
Intermittent pneumatic compression for prevention of pulmonary thromboembolism after gynecologic surgery |
|
| Authors: | Nao Suzuki Fumio Kataoka Atsushi Higashiguchi Takeshi Hirao Sachiko Ezawa Hiroyuki Nomura Akiyo Tomita Nobuyuki Susumu Daisuke Aoki |
| Affiliation: | 1. Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066, EC, Amsterdam, The Netherlands 2. Department of Paediatrics, Dr. Kariadi Hospital, Semarang, Indonesia 3. Institute of Virology, Erasmus Medical Centre, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands 4. Department of Immunopathology, Sanquin Research, P.O. Box 9190, 1006, AD, Amsterdam, The Netherlands 5. Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, Meibergdreef 9, 1100, DD, Amsterdam, The Netherlands 6. Department of Clinical Chemistry, VU Medical Centre, Amsterdam, The Netherlands 7. Hematology and Clinical Chemistry Laboratory, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands 8. Molecular and Cytogenetics Unit, Biotechnology Laboratory, Medical Faculty Diponegoro University, Semarang, Indonesia 10. Cardiovascular Research Institute, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands 9. Department of Internal Medicine, University Hospital Maastricht, P.O. Box 5800, 6202, AZ, Maastricht, The Netherlands 11. Laboratory for Experimental Medicine, Academic Medical Centre, Meibergdreef 9, 1100, DD, Amsterdam, The Netherlands |
| Abstract: | BackgroundDengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 plasma concentrations and with death from dengue is unknown. We, therefore, investigated the relationship between the 4G/5G polymorphism and PAI-1 plasma concentrations in dengue patients and risk of death from dengue.MethodsA total of 194 patients admitted to the Dr. Kariadi Hospital in Semarang, Indonesia, with clinical suspected severe dengue virus infection were enrolled. Blood samples were obtained on day of admission, days 1, 2 and 7 after admission and at a 1-month follow-up visit. Plasma concentrations of PAI-1 were measured using a sandwich ELISA kit. The PAI-1 4G/5G polymorphism was typed by allele-specific PCR analysis.ResultsConcentrations of PAI-1 on admission and peak values of PAI-1 during admission were higher than the values measured in healthy controls. Survival was significantly worse in patients with PAI-1 concentrations in the highest tertile (at admission: OR 4.7 [95% CI 0.9–23.8], peak value during admission: OR 6.3 [95%CI 1.3–30.8]). No association was found between the PAI-1 4G/5G polymorphism, and PAI-1 plasma concentrations, dengue disease severity and mortality from dengue.ConclusionThese data suggest that the 4G/5G polymorphism has no significant influence on PAI-1 concentrations in dengue virus infected patients and is not associated with the risk of death from dengue. Other factors contributing to the variability of PAI-1 plasma concentrations in patients with dengue need to be explored. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |