Metastatic basal cell carcinoma of the posterior neck: case report and review of the literature |
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Authors: | Gropper Adrienne B Girouard Sasha D Hojman Lia P Huang Susan J Qian Xiaohua Murphy George F Vleugels Ruth Ann |
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Affiliation: | Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. |
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Abstract: | Although primary basal cell carcinoma (BCC) represents an extremely common malignancy, metastases derived from BCC are exceedingly rare. The prognosis for metastatic BCC is poor, and little consensus exists regarding predictive factors or optimal treatment strategies. Here, we present the case of a 63-year-old man with BCC of the neck who subsequently developed multiple metastases to subcutaneous tissue, lymph nodes, and the parotid gland. Risk factors and clinical features of metastatic BCC are reviewed, as is the relationship of histopathologic subtype to metastatic behavior. Current chemotherapeutic and targeted therapies also are discussed in the context of recent advances in molecular biology. |
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Keywords: | basal cell carcinoma hedgehog metastasis |
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