肝硬化患者视网膜中动脉的血流动力学变化

目的评价肝硬化患者视网膜中动脉的血流动力学变化。方法30例乙肝肝硬化患者，30例慢性乙肝肝炎患者，及15例正常对照组，分别测量肾动脉、视网膜中动脉、脾动脉RI，门静脉流速（PVV），肠系膜上动脉PI，同时测量肝功能、肾功能和平均动脉压。结果肝硬化患者的CRARI显著增高。CRARI与PVV之间呈负相关（r=-0．59，P〈0．001）。RARI与肝硬化分期也获得相似结果。在肝硬化患者中，CRARI与RARI值之间有显著相关（r=0．39，P〈0．01），CRARI和SARI之间直接相关（r=0．34，P〈0．01）。结论视网膜中动脉可能与肾脏、脾脏的血流动力学变化有关，同样与组织学、门脉高压多普勒参数和血管收缩系统的活性有关。

Hemodynamic alterations of central retinal artery in patients with cirrhosis

Objective To investigate the hemodynamic alterations of central retinal artery in patients with cirrhosis.Methods The indexes of central retinal artery(CRARI),renal artery(RARI),splenic artery(SARI)were measured.Superior mesenteric artery pulsatility index(SMAPI)and portal venous velocity(PVV) were also measured in 30 cirrhotic patients,30 patients with type B chronic liver disease and 15 healthy subjects.Liver and kidney function and mean arterial pressure were also evaluated.Results CRARI was significantly increased in cirrhotic patients and CRARI was inversely correlated with PVV(r=-0.59,P<0.001).The similar results were also obtained between RARI and the stage of the hepatic cirrhotic.In cirrhotic patients, there was a significant correlation between CRARI and RARI(r=-0.39,P<0.01).A direct correlation was found between CRARI and SARI(r=(-0.34),P<0.01).Conclusion CRA seems to be relate to the renal and splenic hemodynamics,also relate to the histology,the Doppler parameters of portal hypertension and the activity of vasoconstrictor systems.