| 烫伤后大鼠肝糖皮质激素受体减少的机理——肾上腺部分切除动物的研究 |
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| 引用本文： | 杨义力,宋亮年,徐仁宝.烫伤后大鼠肝糖皮质激素受体减少的机理——肾上腺部分切除动物的研究[J].第二军医大学学报,1990(2). |
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| 作者姓名： | 杨义力 宋亮年 徐仁宝 |
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| 作者单位： | 第二军医大学病理生理学教研室
(杨义力，宋亮年)，第二军医大学病理生理学教研室(徐仁宝) |
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| 摘 要： | 部分去除肾上腺的大鼠烫伤后,血清糖皮质激素无明显升高,而肝胞液糖皮质激素受体(GR)却有升高的趋势,其中烫伤后6 h组和对照组的相差有非常显著的意义。进一步用打点杂交进行的研究表明,部分去腺大鼠烫伤后6h肝GR mRNA也有增加。这些结果提示,完整动物烫伤时肝胞液GR的减少依赖于血中糖皮质激素的升高。
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| 关 键 词： | 肾上腺 糖皮质激素受体 烫伤 大鼠 |
Mechanisms of the Decrease of Glucocorticoid Receptor in Rat Hepatic Cyto sol after Scalding: Studies on Partial Adrenalectomized Rats |
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| Yang Yili,et al.Mechanisms of the Decrease of Glucocorticoid Receptor in Rat Hepatic Cyto sol after Scalding: Studies on Partial Adrenalectomized Rats[J].Academic Journal of Second Military Medical University,1990(2). |
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| Authors: | Yang Yili |
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| Institution: | Department of Pathophysiology |
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| Abstract: | There was no significant increase of serum glucocorticoid in partial adrenalectomized rats after scalding, whereas glucocorticoid receptor in hepatic cytosol of those rats tended to increase. And 6 h after scalding, the difference between scalded and controlled rats was highly significant. Hepatic glucocorticoid receptor mRNA was also determined by the method of dot blot. It was found that hepatic gluco corticoid receptor mRNA of partial adrenalectomized rats was increased 6h after scalding. Those results suggest that the decrease of hepatic cytosol glucocorticoid receptor in scalded intact rats was dependent on the rise of serum glucocorticoid. |
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| Keywords: | adrenal glucocorticoid receptor scalding rats |
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