A PRELIMINARY CLINICAL STUDY OF CT1341--A STEROID ANAESTHETIC AGENT |
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| Authors: | CAMPBELL, DONALD FORRESTER, ALEX C. MILLER, DONALD C. HUTTON, I. KENNEDY, J. A. LAWRIE, T. D. V. LORIMER, A. R. MCCALL, D. |
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| Affiliation: | University Department of Anaesthetics, Glasgow Royal Infirmary
University Department of Medical Cardiology, Glasgow Royal Infirmary |
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| Abstract: | The effects of a new steroid anaesthetic agent (CT1341) werestudied in twenty volunteers divided into three groups. In groupI, serial measurements were made of heart rate, blood pressureand respiratory rate. In group II, detailed haemodynamic studieswere made in patients undergoing diagnostic cardiovascular investigations.These studies included measurement of cardiac output, strokevolume and arterial blood gases. In group III, time from inductionto "true recovery" was measured following a single intravenousinjection of the drug. This agent produced a stable anaestheticstate in all cases. Anaesthesia was characterized by a risein respiratory rate and pulse rate with a slight fall in systolicand diastolic blood pressure. A significant fall in Pao2 occurredin those patients breathing air. The mean recovery time in sixpatients was 24.3 min. CT1341 produced safe and stable anaesthesiain all twenty cases and is worthy of further clinical trial. |
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