| CD44v6,LN与子宫内膜异位症发病的关系 |
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| 引用本文： | 李风艳,李莉. CD44v6,LN与子宫内膜异位症发病的关系[J]. 山西医科大学学报, 2006, 37(10): 1014-1017 |
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| 作者姓名： | 李风艳 李莉 |
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| 作者单位： | 山西医科大学第一临床医学院妇科,太原,030012 |
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| 摘 要： | 目的探讨细胞黏附分子(CAM)层粘连蛋白(LN)、CD44v6与子宫内膜异位症发病的关系。方法采用光镜和SP免疫组化法对子宫内膜异位症在位内膜(22例)、异位内膜(45例)、对照组子宫内膜(20例)进行病理组织化学观察和CD44v6,LN表达的检测。结果CD44v6主要表达于子宫内膜腺上皮细胞,LN表达于基质细胞,与对照组相比子宫内膜异位症者在位子宫内膜CD44v6,LN均表达下降,差异有统计学意义(P<0.05),异位内膜组CD44v6、LN表达明显降低,差异有统计学意义(P<0.05)。结论子宫内膜异位症患者从子宫内膜到异位病灶,CD44v6,LN均有明显的变化,这可能与子宫内膜异位症的发生、发展、不孕有关。
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| 关 键 词： | 子宫内膜异位症 细胞黏附分子 层粘连蛋白 |
| 文章编号： | 1007-6611（2006）10-1014-04 |
| 收稿时间： | 2006-10-01 |
| 修稿时间： | 2006-10-01 |
Correlations of CD44v6 and laminin expression with endometriosis |
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| LI Feng-yan,LI Li. Correlations of CD44v6 and laminin expression with endometriosis[J]. Journal of Shanxi Medical University, 2006, 37(10): 1014-1017 |
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| Authors: | LI Feng-yan LI Li |
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| Affiliation: | Dept of Cynecology , First Clinical Medical College, Shanxi Medical University, Taiyuan 030012, China |
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| Abstract: | Objective To explore the relations between the expression of CD44v6 and laminin and endometriosis. Methods Expression of CD44v6 and laminin were evaluated by immunohistochemistry in entopic endometrium from 22 patients and in ectopic endometrium from 45 patients with endometriosis and the endometrial tissues of 20 controls without endometriosis. Results CD44v6 was restricted to epithelial cells;laminin was restricted to stoma.Expression of CD44v6 and laminin in epithelial and stoma in endometriosis decreased in eutopic endometrium and ectopic endometrium(P<0.05) compared with endometrium in controls. Conclusion In patients with endometriosis expression of CD44v6 and laminin changs significantly from eutopic to ectopic endometrium,which may be related to the development of endometriosis and infertility. |
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| Keywords: | CD44v6 |
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