藻酸双酯钠对银屑病病人白细胞流变特性及细胞黏附分子表达的影响

①目的 探讨白细胞流变特性及白细胞黏附分子（ＣＡＭｓ）表达与银屑病关系，及藻酸双酯钠（ＰＳＳ）对其影响。③方法 采用ＤＸＣ－３００Ａ型核孔滤膜红细胞变形能力测定仪、体外血栓血小板黏附两用仪及ＥＬＩＳＡ性细胞间黏附分子－１（ｓＩＣＡＭ－１）含量的变化。③结果 银屑病病人白细胞滤过指数（ＬＦＩ）、白细胞黏附率（ＬＡＲ）、白细胞ＣＤ１８表达及ｓＩＣＡＭ－１含量明显增高，与对照组比较差异有极显著性（ｔ＝６

THE EFFECT OF POLYSACCHRIDE SULFATE ON THE LEUKOCYTE RHEOLOGICAL CHARACTERISTICS AND THE EXPRESSION OF CELL ADHESION MOLECULES IN PATIENTS WITH PSORIASIS

Objective To explore the relationship between the changes of leukocyte rheological characteristics and expression of cell adhesion molecules and psoriasis, and the effect of polysacchride sulfate(PSS) on them. Methods By using the DXC 300A erythrocyte deformability apparatus, platelet and thrombus adhesion dual purpose apparatus and enzyme linked immunosorbent assay (ELISA) methods, the changes of leukocyte deformability (LD),leukocyte adhesion function(LAF),leukocyte CD 18 expression and serum soluble intercellular adhesion molecule 1 (sICAM 1) were measured in patients with psoriasis before and after treatment with PSS. Results The leukocyte filtration index(LFI) ,leukocyte adhesion rate(LAR), leukocyte CD 18 expression and sICAM 1 concentration were significantly higher in patients with psoriasis than those in controls(t=6.860-22.650, P<0.01). LFI, LAR were positively correlated to leukocyte CD 18 expression and sICAM 1 concentration(r=0.716,0.625, 0.600 ,0.596, P<0.001) and LFI was positively correlated to LAR (r=0.607, P<0.001). The LFI, LAR, CD 18 expression and sICAM 1 concentration were significantly lower in the patients after treatment with PSS than those in the patients before treatment (t=17.362-56.601, P<0.001). Conclusion The abnormalities of leukocyte rheological characteristics and cell adhesion molecules expression may participate in the occurance and development of psoriasis, and PSS may have the effects of improving the leukocyte rheological characteristics and restraining the expression of cell adhesion molecules.;