Late effects of treatment for early-stage Hodgkin's disease. |
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Authors: | J. D. Brierley A. J. Rathmell M. K. Gospodarowicz S. B. Sutcliffe A. Munro R. Tsang M. Pintilie |
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Affiliation: | University of Toronto, Department of Radiation Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Canada. |
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Abstract: | A comprehensive survey of late effects (physical, social and reproductive) following treatment at a single institution for early stage Hodgkin''s disease (HD) was performed. A total of 611 patients with stage I and II HD treated between 1973 and 1984 were reviewed; 460 were alive and were mailed a self-reported questionnaire. A total of 363 (79%) replies were received. Twenty patients died of second malignancy, 14 of heart disease and nine from respiratory disease. There were 37 cases of second malignancy [relative risk (RR) 2.2, absolute excess risk (AR) 35.8]. The 15-year incidence of heart disease was 11% and there were nine myocardial infarction deaths (RR 1.55, AR 5.4). Twenty-eight (8%) respondents stated that their career had been greatly interfered with, 53 (14.5%) perceived financial loss. Sexual activity was disrupted in 25.8%. In total, 56 men had fathered 112 pregnancies. Of 171 women, 40.3% became pregnant, resulting in 92 live births. A total of 43 men and 16 women had sought medical advice with regard to infertility. |
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