Plasma insulin-like growth factor in primary breast cancer patients treated with adjuvant chemotherapy. |
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| Authors: | J. P. Peyrat F. R??villion J. Bonneterre |
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| Affiliation: | Laboratoire d''Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France. |
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| Abstract: | Insulin-like growth factor 1 (IGF-1) plasma level was assayed in 60 breast cancer patients undergoing six courses of adjuvant chemotherapy. The only observed variation was a slight decrease (10%) in IGF-1 concentrations, assayed before treatment, between the first and the second courses of chemotherapy. During chemotherapy courses, there were no statistically significant variations in IGF-1. These results suggest that chemotherapy, unlike the specific hormonal treatments tamoxifen and somatostatin, certainly does not act via a decrease in plasma IGF-1. |
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