| 纳络酮对缺血再灌注心肌脂质过氧化物和钙含量的影响 |
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| 引用本文： | 杨天德,刘桥义,王舟琪.纳络酮对缺血再灌注心肌脂质过氧化物和钙含量的影响[J].中国现代应用药学,1996(3):3-4. |
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| 作者姓名： | 杨天德 刘桥义 王舟琪 |
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| 作者单位： | 第三军医大学新桥医院麻醉科 |
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| 摘 要： | 利用大心肌缺血、再灌注模型，观察了纳络酮对缺血再藻注心肌脂质过氧化物（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）和钙含量的影响。结果表明：缺血、再灌注心肌ＬＰＯ和钙含量明显增加（Ｐ＜０．０５，Ｐ＜０．０１），再灌注心肌ＬＰＯ含量和钙含量明显高于缺血心肌（Ｐ＜０．０５，Ｐ＜０．０１），而缺血、再灌注心肌ＳＯＤ明显降低（Ｐ＜０．０１）；纳络用明显降低缺血、再灌注心肌ＬＰＯ和钙含量（Ｐ＜０．０５，Ｐ＜００１），但对ＳＯＤ的影响不明显（Ｐ＞０．０５）。提示：纳络酮抑制心肌缺血、再灌注时的脂质过氧化物反应，部份阻止细胞外钙跨膜内流，对心肌只响保护作用。
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| 关 键 词： | 脂质过氧化物，超氧化物歧化酶，钙心肌缺血再灌注，纳络酮，犬 |
Effects of Naloxone on Lipid Peroxide and Calcium Content of Canine Myocardium During Ischemia and Reperfusion |
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| Yang Tian-de,Liu Qiao-Yi,Wang Zhou-qi.Effects of Naloxone on Lipid Peroxide and Calcium Content of Canine Myocardium During Ischemia and Reperfusion[J].The Chinese Journal of Modern Applied Pharmacy,1996(3):3-4. |
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| Authors: | Yang Tian-de Liu Qiao-Yi Wang Zhou-qi |
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| Abstract: | The effects of naloxone on lipid peroxode (LPO), superoxide dismutase(SOD)and calcium content were examined in canine ischemic and reperfused myocardium.Results showed that, in ischemic and reperfused myocardium, LPO and calcium content were obviously increased (p<0.05,p<0.01);SOD was remarkably decreased (p<0.01);Noloxone decreased LPOand calcium significatly (p<0.05,p<0.01) and had on effect on SOD (p>0.05) . It suggested that naloxone may inhitib lipid peroxidation and prevent influx of calcium to some extend in ischemic and reperfused myocardium. |
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| Keywords: | :lipid peroxide superoxide dismutase calmutase calcium myocardial ischemia and rep-erfusion naloxone |
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