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Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens |
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| Authors: | Tiffany C. Scharschmidt MD Mao-Qiang Man MD Yutaka Hatano MD Debra Crumrine Roshan Gunathilake MD John P. Sundberg DVM PhD Kathleen A. Silva BS Theodora M. Mauro MD Melanie Hupe BS Soyun Cho MD PhD Yan Wu MD Anna Celli PhD Matthias Schmuth MD Kenneth R. Feingold MD Peter M. Elias MD |
| Affiliation: | aDermatology Service, Veterans Affairs Medical Center, and the Department of Dermatology, University of California, San Francisco, Calif;bExperimental Dermatology and General Mouse Pathology, The Jackson Laboratory, Bar Harbor, Me;cDepartment of Dermatology, Seoul National University College of Medicine and Boramae Hospital, Seoul, South Korea;dDepartment of Dermatology, First Hospital, Peking University, Beijing, China |
| Abstract: | |
| Keywords: | Atopic dermatitis barrier function contact dermatitis filaggrin flaky-tail mouse lamellar body |
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