冠状动脉造影术造影剂与肾功能关系的研究

目的探讨冠状动脉造影术中造影剂对肾功能的影响。方法①按患者所用造影剂的量分成50~100ml组、100~200ml组和>200ml组。②分别测定术前、术后24h、术后48h、术后10d的血尿素氮(BUN)、血肌苷(Cr)、尿微量白蛋白(MAU)、尿β2-微球蛋白(β2MG)的值并进行比较。结果造影后24h、48h尿β2MG与造影前及造影后10d比较有显著性差异(P<0.05),其余指标各时段之间比较无显著性差异(P>0.05)。造影后24h、48h造影剂>200ml组与50~100ml组及100~200ml组之间Cr、MAU及β2MG的变化有显著性差异(P<0.05)。其余各组之间比较无显著性差异(P>0.05)。结论造影剂对肾功能有一定的损害,并且随造影剂剂量的增加其损害加重。

Relation between contrast medium and kidney function in coronary angiography

Objective To investigate the relation between contrast medium and kidney function in coronary angiography. Methods ① According to the dosage of contrast medium, patients were divided into three groups: 50～100ml, 100～200ml and above 200 ml. ② Blood BUN,Blood Cr, albuminuria and urine β2 MG levels of all patients were measured before coronary angiography and after coronary angiography 24h,48h,10d. Results The levels of urine β2 MG after coronary angiography 24h and 48h were higher than before coronary angiography and after coronary angiography 10d(P<0.05), the other groups were no significantly different in statistics(P>0.05). The Blood Cr,Albuminuria and urine β2 MG levels after coronary angiography 24h and 48h in the group above 200 ml were higher than in the group 50～100ml and 100～200ml(P<0.05), the other groups were no significantly different in statistics(P>0.05). Conclusion Contrast medium injures kidney in coronary angiography and the deterioration of kidney function is related with the dose of contrast medium.