Effect of Low-Dose Aspirin on the Markers of Oxidative Stress |
| |
Authors: | Tiina Ristimäe Mihkel Zilmer Kersti Zilmer Czeslawa Kairane Tiiu Kullisaar Rein Teesalu |
| |
Affiliation: | (1) Department of Cardiology, Faculty of Medicine, University of Tartu, Tartu, EE 51014, Estonia;(2) Department of Biochemistry, Faculty of Medicine, University of Tartu, Tartu, Estonia |
| |
Abstract: | Summary. The present study estimates effects of low-dose enteric coated aspirin (ECA) on oxidative stress (OS) markers in a group of middle-aged men (mean age 51.2 ± 6.9 years) free of pre-existing ischemic heart disease.Methods. Serum products of lipid peroxidation, and measures of antioxidative status were detected in 25 healthy men in baseline and after two-week treatment period.Results. In respect to serum products of lipid peroxidation and markers of antioxidant status, no statistically significant differences between the pre- and after-treatment data were observed for any measures, with the exception of values of serum antioxidative capacity (39.0 ± 2.5 and 42 ± 4.6, respectively).Conclusions. Administration of ECA does not initiate the OS in blood and improves the general antioxidative potency of blood. This may imply towards certain antiatherogenic influence of low-dose ECA, exhibited even with a short-term treatment period. Regarding OS markers, a variety of individual responses observed in the selected subgroups should be investigated and possibly taken into account while treatment with ECA is initiated for primary prevention of cerebrovascular events. |
| |
Keywords: | low-dose aspirin healthy middle-aged subjects oxidative stress |
本文献已被 PubMed SpringerLink 等数据库收录! |
|