INCREASED PLASMA ACTIVITIES OF N-ACETYL-β-D-GLUCOSAMINIDASE ISOENZYMES IN HUMAN DIABETES MELLITUS |
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| Authors: | P. Y. W. POON T. L. DORNAN R. B. ELLIS R. C. TURNER |
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| Affiliation: | Department of the Regius Professor of Medicine, University of Oxford, Radcliffe Infirmary, Oxford;Institute of Child Health, 30 Guilford Street, London |
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| Abstract: | Plasma N-acetyl-beta-D-glucosaminidase activities are raised in maturity-onset insulin-dependent diabetic patients. Continuous gradient DEAE-cellulose column chromatography and assay of heat-stable enzyme activity both show that the activities of all isoenzymes are equally increased rather than a previously described increase of specific isoenzymes. Plasma enzyme activities are similarly increased in patients with and without diabetic retinopathy, and correlate with simultaneous plasma glucose concentrations. |
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