Amino acid transport in cerebral microvessels during plasmodium yoelii infection in mice |
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Authors: | Anju Agrawal LM Tripathi VC Pandey |
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Institution: | a Division of Biochemistry, Central Drug Research Institute Lucknow-226001 India |
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Abstract: | Plasmodium yoelii infected cerebral microvessels of mice had an enhanced time-dependent, temperature-sensitive, and saturable uptake of 14C]-amino acid. viz. leucine, valine and glycine. Metabolic inhibitors caused a noticeable inhibition of amino acid uptake in normal microvessels as compared to infected cerebral microvessels indicating that the uptake of 14C]-L-leucine, 14C]-L-valine and 14C]-glycine is an energy dependent process. |
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Keywords: | cerebral microvessels amino acids malaria blood-brain-barrier |
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