| 3种细胞粘附分子表达与乳腺癌临床病理特征和预后的关系 |
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| 引用本文： | 谷化平,尚培中,倪灿荣. 3种细胞粘附分子表达与乳腺癌临床病理特征和预后的关系[J]. 解放军医学杂志, 2002, 27(8): 732-734 |
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| 作者姓名： | 谷化平 尚培中 倪灿荣 |
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| 作者单位： | 张家口,解放军第251医院,075000;第二军医大学长海医院 |
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| 摘 要： | 探讨了唾液酸化的路易斯寡糖－X（sialyl Lewis-X,SLeX）抗原，CD44v6和E－上皮钙粘附素（E－cadherin,ED）表达与乳腺癌临床病理生物学行为的关系。应用免疫组化法，对94例乳腺癌组织进行SLeX、CD44v6和ED蛋白检测。结果显示，SLeX、CD44v6阳性表达及ED阴性表达均与乳腺癌的组织学分级、临床分期、淋巴结转移、复发和预后呈 相关。结果表明，SLeX、CD44v6和ED表达对估计乳腺癌淋巴结转移及患者生存期有重要意义，可作为判断乳腺癌的转移和预后的参考指标。
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| 关 键 词： | 乳腺肿瘤 细胞粘附分子 肿瘤转移 预后 |
| 修稿时间： | 2002-03-25 |
CORRELATION BETWEEN EXPRESSION OF THREE CELL ADHESION MOLECULES AND CLINICAL PATHOLOGY CHARACTER AND PROGNOSIS IN BREAST CANCER |
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| Gu Huaping,Shang Peizhong,Ni Canrong. Hospital of PLA,Zhangjiakou. CORRELATION BETWEEN EXPRESSION OF THREE CELL ADHESION MOLECULES AND CLINICAL PATHOLOGY CHARACTER AND PROGNOSIS IN BREAST CANCER[J]. Medical Journal of Chinese People's Liberation Army, 2002, 27(8): 732-734 |
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| Authors: | Gu Huaping Shang Peizhong Ni Canrong. Hospital of PLA Zhangjiakou |
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| Affiliation: | Gu Huaping,Shang Peizhong,Ni Canrong. 251 Hospital of PLA,Zhangjiakou 075000 |
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| Abstract: | To investigate the relationship of expression of sialyl Lewis X (SLeX) antigen,CD44v6 and E cadherin(ED) with staging,infiltration,node metastasis and prognosis in breast cancer, immunohistochemical method was used to detect their expression in 94 cases of breast cancer.The positive expression of SLeX,CD44v6 and the negative expression of ED were positively correlated with the grading, clinical staging, lymph node metastasis recurrence and prognosis of breast cancer.The results demonstrated that the expression of SLeX, CD44v6 and ED as a clinical valuable marker,has a great significance in assessing node metastasis and prognosis. |
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| Keywords: | breast neoplasms cell adhesion molecules neoplasm metasthsis prognosis |
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