慢性粒细胞白血病预后因素回顾性队列研究

目的 研究影响慢性粒细胞白血病（ＣＭＬ）生存的预后因素。方法 回顾性队列研究１５８例ＣＭＬ的病例资料,生存曲线用Ｋａｐｌａｎ－Ｍｅｉｅｒ法,预后因素单变量分析用Ｌｏｇｒａｎｋ检验,多变量分析用逐步Ｃｏｘ回归模型。结果 中位生存时间１４８０ｄ（４年）,５年生存率４７．１％（９５％ＣＩ,３６．７％～５６．９％）,１０年生存率２４．８％（９５％ＣＩ,１５．０％～３５．８％）。急变类型以急粒变、急粒单变和

Retrospective cohort study on the prognosis of chronic myeloid leukemia

OBJECTIVE: To evaluate the prognostic factors of chronic myeloid leukemia (CML). METHODS: Survival curves were plotted according to the Kaplan-Meier method. Variables associated with prognosis were analyzed by Logrank test. A multivariate analysis of prognostic factors was performed using stepwise Cox model. RESULTS: Of the total 158 patients, the median survival time was 1,480 days. 5 years survival rate was 47.1% (95% CI, 36.7% - 56.9%). 10 years was 24.8% (95% CI, 15.0% - 35.8%). The predominant blastic crisis type is myeloblastic, myelomonocytic or monocytic(77.5%). The period from chronic phase to blastic phase was equal in myelosuppressive therapy group, non- myelosuppressive therapy group or altretamine (HMM) group. After evaluated by stepwise Cox's regression model, age>or=50 years, bone marrow blasts>or=0.05, bone marrow basophilic>or=0.05, Ph chromosome negative and HMM treatment were associated with poor prognosis. Hydroxyurea was always associated with longer survival. CONCLUSION: Age, Ph chromosome, bone marrow blasts and basophilic, and various treatment affected the survival of CML.