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| 阿昔洛韦眼用凝胶在兔离体角膜中的渗透释药行为研究 | |
| 引用本文： | 卢荣枝,唐干益,宫琦.阿昔洛韦眼用凝胶在兔离体角膜中的渗透释药行为研究[J].中国药房,2006,17(4):258-260. |
| 作者姓名： | 卢荣枝 唐干益 宫琦 |
| 作者单位： | 1. 广东中山市人民医院,中山市 528403 2. 广东深圳市流花医院,深圳市 518005 3. 四川江油市人民医院,江油市 621700 |
| 摘 要： | 目的:研究阿昔洛韦眼用凝胶在兔离体角膜中的渗透释药行为。方法:以谷胱甘肽缓冲液作为释放介质,采用高效液相色谱法测定阿昔洛韦眼用凝胶及阿昔洛韦滴眼液在兔离体角膜中的累积渗透释药量,并绘制曲线。结果:阿昔洛韦眼用凝胶的渗透释药曲线符合一级释药方程;0·25h时阿昔洛韦滴眼液的累积渗透释药量高于阿昔洛韦眼用凝胶,0·25h以后则相反。结论:在给药后很短时间内(0·25h),阿昔洛韦滴眼液的房水药物浓度要高于阿昔洛韦眼用凝胶,但凝胶在眼部滞留时间较长,且角膜有一定的药物储库作用。 |
| 关 键 词： | 阿昔洛韦 眼用凝胶 高效液相色谱法 离体角膜 渗透释药 |
| 文章编号： | 1001-0408(2006)04-0258-03 |
| 收稿时间： | 11 11 2005 12:00AM |
| 修稿时间： | 2005年11月11 |
Behavioral Study on Osmotic Releasing of Acyclovir Eye- gels in Isolated Cornea of Rabbits |
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| LU Rongzhi,TANG Ganyi,GONG Qi.Behavioral Study on Osmotic Releasing of Acyclovir Eye- gels in Isolated Cornea of Rabbits[J].China Pharmacy,2006,17(4):258-260. | |
| Authors: | LU Rongzhi TANG Ganyi GONG Qi |
| Abstract: | OBJECTIVE:To study the osmotic releasing of acyclovir in isolated cornea of rabbits.METHODS:The cuˉmulative osmotic drug releasing amount of acyclovir eye-gels and acyclovir eye-drops in the isolated corneal of rabbits were determined by HPLC with glutathion buffer as releasing medium.Meanwhile the curves of drug releasing were drawn.REˉSULTS:The osmotic drug releasing of acyclovir eye-gels conformed to the first-order kinetics equation.The cumulative osmotic drug releasing amount of acyclovir eye-drops was higher than that of eye-gels at0.25h;however,it worked in reˉverse thereafter.CONCLUSION:Within a short time after administration(0.25h),aqua oculi drug concentration of acyclovir eye-drops was higher than that of acyclovir eye-gels,while the retention time of eye-gels was longer and cornea serves as drug reservoir to some degree. |
| Keywords: | Aciclovir Eye - gels HP LC Isolated cornea Osmotic releasing |
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