Relationship between characteristics on magnetic resonance imaging and motor outcomes in children with cerebral palsy and white matter injury |
| |
| Affiliation: | 1. Developmental Disability and Rehabilitation Research, Murdoch Childrens Research Institute, 50 Flemington Road, Parkville 3052, VIC, Australia;2. Department of Paediatrics, University of Melbourne, Parkville 3052, VIC, Australia;3. Department of Diagnostic Imaging, Monash Children''s Hospital, 246 Clayton Road, Clayton 3168, VIC, Australia;4. Medical Imaging Department, Royal Children''s Hospital, 50 Flemington Road, Parkville 3052, VIC, Australia;1. Dipartimento di Psicologia dello Sviluppo e della Socializzazione, Università di Padova, Italy;2. Dipartimento di Psicologia Generale, Università di Padova, Italy;1. Department of Pediatrics, Aichi Medical University, Japan;2. Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan;3. Department of Pediatric Neurology, Bobath Memorial Hospital, Japan;4. Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Japan;5. Department of Pediatrics, Shiga University of Medical Science, Japan;6. Department of Pediatrics, Faculty of Medicine, Kagawa University, Japan;7. Division of Neonatal Medicine, Department of Pediatrics, Saitama Medical University Hospital, Japan;8. Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Japan;1. KU Leuven – University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium;2. UHasselt – Hasselt University, BIOMED, Rehabilitation Research Center (REVAL), Diepenbeek, Belgium;3. IRCCS Stella Maris Foundation, Pisa, Italy;4. KU Leuven – University of Leuven, Department of Imaging and Pathology, Leuven, Belgium;5. The University of Queensland, Queensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Medicine and Science, Brisbane, Australia;6. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy;7. KU Leuven – University of Leuven, Department of Development and Regeneration, Leuven, Belgium;1. Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, School of Medicine, Beer Sheva, Israel;2. Center of Clinical Research, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel;3. Department of Obstetrics and Gynecology, Azienda Ospedaliera Universitaria Policlinico di Bari, Universita’ degli Studi di Bari “Aldo Moro”, School of Medicine, Bari, Italy;1. Department of Pediatric Radiology, Children''s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA;2. Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;3. Department of Radiology, Children''s Hospital Los Angeles, Los Angeles, CA, USA;4. Brain and Creativity Institution, University of Southern California, Los Angeles, CA, USA |
| |
| Abstract: | In a population cohort of children with white matter injury (WMI) and cerebral palsy (CP), we aimed to describe the magnetic resonance imaging (MRI) characteristics, identify key structure–function relationships, and classify the severity of WMI in a clinically relevant way. Stratified on MRI laterality/symmetry, variables indicating the extent and location of cerebral abnormalities for 272 children with CP and WMI on chronic-phase MRI were related to gross motor function and motor topography using univariable and multivariable approaches. We found that symmetrical involvement, severe WM loss in the hemispheres and corpus callosum, and cerebellar involvement were the strongest predictors of poor gross motor function, but the final model explained only a small proportion of the variability. Bilateral, extensive WM loss was more likely to result in quadriplegia, whereas volume loss in the posterior-mid WM more frequently resulted in diplegia. The extent and location of MRI abnormalities differed according to laterality/symmetry; asymmetry was associated with less extensive hemispheric involvement than symmetrical WMI, and unilateral lesions were more focal and located more anteriorly. In summary, laterality/symmetry of WMI, possibly reflecting different pathogenic mechanisms, together with extent of WM loss and cerebellar abnormality predicted gross motor function in CP, but to a limited extent. |
| |
| Keywords: | Cerebral palsy Magnetic resonance imaging White matter injury Periventricular leukomalacia Intraventricular haemorrhage |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
