Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders |
| |
| Institution: | 1. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America;2. Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America;3. Departments of Neurology and Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, United States of America;4. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States of America;5. Department of Psychology, University of Georgia, Athens, GA, United States of America;6. Psychiatry, University of Chicago, Chicago, IL, United States of America;7. Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States of America;8. Departments of Psychiatry and Neurobiology, Yale University and Olin Neuropsychiatric Research Center, Hartford, CT, United States of America;9. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States of America;1. School of Electrical Engineering and Telecommunications, The University of New South Wales, Kensington, NSW 2052, Australia;2. Data61, Level 5, 13 Garden Street, Eveleigh, NSW 2015, Australia |
| |
| Abstract: | Atypical pupillary light reflexes (PLR) has been observed in children with autism spectrum disorders (ASD), which suggests potential autonomic nervous system (ANS) dysfunction in ASD. ANS is also involved in modulating sensory processing and sensory dysfunction has been widely reported in children with ASD. However, the potential association between physiological measurements of PLR and behavioral observations (e.g. sensory behaviors) has not been examined extensively in literature. In this study, we investigated the potential correlation between PLR and frequently observed sensory behaviors in children with ASD. We found a significant association between PLR constriction amplitude and a set of sensory behaviors in the ASD group but not in typically developing children. Children with ASD who showed more atypical sensory behaviors also had smaller PLR constriction amplitudes. A smaller PLR constriction amplitude suggests lower parasympathetic modulation. This observation implies that some atypical sensory behaviors in children with ASD could be associated with decreased parasympathetic modulation. |
| |
| Keywords: | Pupillary light reflex Autism Sensory Autonomic nervous system |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
