S-100B is increased in melancholic but not in non-melancholic major depression |
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Authors: | Rothermundt M Arolt V Wiesmann M Missler U Peters M Rudolf S Kirchner H |
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Affiliation: | Department of Psychiatry, University of Muenster, Albert-Schweitzer-Str. 11, D-48129 Muenster, Germany. rothermu@uni-muenster.de |
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Abstract: | BACKGROUND: Recent evidence suggests that neurodegeneration may be involved in the pathophysiology of major depression. The astroglial peptide S-100B was shown to be increased in many diseases causing neuronal cell damage or degeneration. METHOD: S-100B plasma levels were determined in 28 patients with major depression and 28 matched healthy controls using an immunofluorometric sandwich assay. RESULTS: Patients suffering from melancholic depression showed significantly increased S-100B levels compared to healthy controls while non-melancholic patients demonstrated normal levels. LIMITATIONS: Medication of patients varied. The differentiation between melancholic and non-melancholic patients was performed clinically without using a standardized instrument. CONCLUSIONS: Neurodegeneration or axonal remodeling may be involved in the pathogenesis of melancholic depression. |
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