鼠舌神经损伤后菌状乳头变化的扫描电镜研究

目的 :了解舌神经损伤后菌状乳头的变化和再生能力。方法 :将成年SD大鼠的一侧舌神经模拟临床损伤后 ,用体视显微镜结合扫描电镜 ,定量观察大鼠舌菌状乳头的变化。结果 :(1)舌神经被钳夹或切断后 ,同侧的菌状乳头萎缩 ,消失 ,数目明显减少 ,味孔消失。 (2 )舌神经被钳夹后 65天 ,萎缩消失的菌状乳头明显再生 ,形态和数目恢复正常 ;(3)舌神经被切断后90天 ,萎缩消失的菌状乳头仍然没有再生迹象。结论 :(1)菌状乳头及其味蕾对舌神经具有依赖性 ;(2 )菌状乳头有很强的再生能力 ,能否再生与舌神经的损伤程度和修复有关 ;(3)舌神经不仅有支配和营养菌状乳头及其味蕾的作用 ,而且还有抑制菌状乳头向丝状乳头异化的功能。

The Scanning Electron Microscope Study on Changes of Fungiform Papillae Following Injury to Lingual Nerve in Rat

Objective:To investigate the changes of fungiform Papillae following injury to lingual nerve.Methods:The unilateral lingual nerves were injured with clinical imitation in 40 adult SD rats,The changes of the fungiform papillae were observed with steromicroscope and scanning electron microscope after injury of lingual nerve.Results:(1)Following either the clamp injury or transecting injury of lingual nerve,the fungiform papillae were atrophied and their number deminished.The shape of the fungiform papillae collapsed and the taste pore of the papilla of disappeared.(2)65 days following the clamp injury of lingual nerve the degenerated fungiform papillae were regenerated and rehabilitated.(3)90 days following the transection of lingual nerve,there was no any regeneration of the degenerated fungiform papillae.Conclusion:(1)The fungiform papilla as well as taste bud depends on the lingual nerve.(2)The fungiform papilla has good ability to regenerate.whether the degenerated fungiform papilla can regenerate is relative to the injured degree and repair of lingual nerve.(3)Lingual nerve not only supports fungiform papilla and taste bud,but also suppresses the filiform like degeneation of fungiform papilla.