金湖县1999～2003年狂犬病疫苗免疫效果分析

目的了解人群接种狂犬病疫苗后机体血清学免疫效果。方法对金湖县1999-2003年狂犬病病毒抗体检测结果进行统计分析。结果狂犬病病毒抗体总阳性率为94.16%,各年间血清学免疫效果不同;注射浓缩苗的阳性率低于注射精制苗的标本;不同季节阳性率不同,春夏季低于秋冬季;不同性别之间血清学免疫效果差异无显著性;各年龄组血清学免疫效果不同,小于10岁年龄组阳性率最高,70岁以上年龄组阳性率最低;青少年组、中年组、老年组三者中,中年组阳性率最低。结论国产狂犬病疫苗质量比较稳定,免疫效果可靠,而且精制苗的保护作用更为明显。

Analysis on Immunological Efficacy of Rabies Vaccine in Jinhu County from 1999 to 2003

Objective This study was designed to learn about the serological post-immunization effectiveness of rabies vaccine among people. Methods Statistic analysis was used for testing results of antibodies against rabies virus from 1999 to 2003 in Jinhu County. Results The overall positive rate of rabies antibody was 94.16%, with differences of serological immunization effectiveness each year; concentrated vaccines had a lower positive rate of antibodies than purified vaccine samples; different positive rates were found in distinct seasons with those in spring and summer lower than in autumn and winter; there were no significant difference in serological immunization efficacy among people at different ages; among each age groups, serological immunization efficacy varied, with the highest positive lying in the group below 10 years old and the lowest in people over 70; among 3 groups of juvenile, middle-aged and senior people, the positive rate in middle-aged group was the lowest. Conclusion Domestic rabies vaccines have a stable quality and reliable immunization effectiveness and purified vaccines have more conspicuous protective effects.