绝经后女性冠心病患者雌激素、C反应蛋白与白介素6水平变化及其关系

目的探讨绝经后女性冠心病患者体内雌激素、C反应蛋白与白介素6水平的变化以及雌激素与C反应蛋白、白介素6的关系。方法对31例符合要求的绝经后女性冠心病患者与44例非冠心病患者股动脉采血检测雌二醇、C反应蛋白与白介素6的浓度。结果冠心病组的雌激素水平明显低于非冠心病组(18±7)vs(24±10)ng/L,P0.05,而C反应蛋白与白介素6水平则明显高于非冠心病组(6.9±5.9)vs(1.9±1.3)mg/L;(59±11)vs(46±13)ng/L,P0.01。雌二醇与C反应蛋白、白介素6没有明显的相关性(r=-0.106,-0.203,P0.05)。结论雌二醇、C反应蛋白和白介素6在绝经后女性冠心病的发病中起着重要的作用。雌激素影响女性冠心病的发病与C反应蛋白以及白介素6没有明显的相关性。

Levels of plasma estrogen,C-reactive protein and interleukin-6 in postmenopausal female patients with coronary heart disease and their mutual relationship

Objective To investigate the levels of plasma estrogen,C-reactive protein （CRP） and interleukin （IL）-6 in postmenopausal female patients with coronary heart disease （CHD） and the association of estrogen level with CRP and IL-6 levels.Methods The plasma levels of estrogen,CRP and IL-6 were measured in 31 postmeno-pausal females with CHD and 44 ones without CHD.Results Plasma level of estrogen was obviously lower （18±7）vs （24±10）ng/L,P0.05,while levels of CRP and IL-6 were obviously higher （6.9±5.9）vs （1.9±1.3）mg/L;（59±11） vs （46±13） ng/L,P0.01 in CHD patients than in non-CHD ones.The plasma level of estrogen had no association with that of CRP and IL-6 （r=-0.106,-0.203,P0.05 ）.Conclusion Estrogen,CRP and IL-6 play important roles in the pathogenesis of CHD in postmenopausal female patients.The effect of estrogen on the pathogenesis of CHD in female patients has no association with CRP and IL-6.