西拉普利对脑梗塞伴高血压患者运动及认知功能的影响

目的探讨西拉普利对脑梗塞伴高血压患者日常生活能力及认知功能的影响。方法将42例脑梗塞伴高血压患者随机分为西拉普利治疗组22例和常规治疗组20例。西拉普利组给予一平苏2.5mg～5mg，每日一次；常规治疗组给予心痛定和／或利尿剂治疗。两组均行运动治疗、作业治疗及神经营养，治疗过程中每日两次测血压，在治疗前及治疗6周后采用简式Fugl-Meyer评估及Barthel指数分别评定肢体运动功能及日常生活能力(ADL)，采用简明精神状态检查（MMSE）评估认知功能。结果两组降压显效率及有效率无显著性差异，但西拉普利治疗组血压波动较小。与常规组比较，治疗组日常生活能力评分增高显著(P<0.05)，且下肢运动功能恢复明显。治疗组认知功能评分与常规组比较无统计学差异，但治疗组定向力及记忆力改善明显优于常规组(P<0.05)。结论西拉普利降压效果稳定可靠，可改善脑梗塞伴高血压患者日常生活能力及认知功能。

The Effect of Cilazapril on the Motor and Cognitive Function in Cerebra l Infarction with Hypertension.

Objective To explore the effect of cilazapril on motor and cognitive function in hypertension with brain stroke. Method 42 hypertensive patients with stroke were divided into cilazapril treatment group(22 cases) and traditi onal treatment group (20 cases). The cilazapril group was treated with Inhibace 2.5 mg～5 mg daily. The traditional group was treated with nifedipine and/or di uretic. The blood pressure was measured twice a day during the treatment course. The activity of daily living (ADL), motor and cognitive function were assessed with Barthel index, Fugl-Meyer and MMSE assessment respectively before and 6 we eks after treatment.Results There were no difference between the two groups on blood pressure effectiveness, but blood pressure was more stable in the cilazapril gro up. Improvement of ADL and lower limb motor function in cilazapril treatment gro up were improved significantly than those of traditional treatment group(P<0.05). Although there was no difference between the two groups in the total value of cognitive function assessment, but the directional ability and memory function in group wa s higher than those in traditional group (P<0.05). Conclusion Cilazapril can decrease blood pressure steadily and can improve the activity of daily living and cognitive function in stroke patients.