| 布地奈德雾化吸入对轻中度支气管哮喘患者Th1/Th2细胞因子平衡的影响 |
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| 引用本文： | 左志通,陈宝华,王旭,张彩娣,邹新中,史建平.布地奈德雾化吸入对轻中度支气管哮喘患者Th1/Th2细胞因子平衡的影响[J].临床肺科杂志,2010,15(2):177-178. |
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| 作者姓名： | 左志通 陈宝华 王旭 张彩娣 邹新中 史建平 |
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| 作者单位： | 无锡,南通大学第三附属医院(无锡市第三人民医院)呼吸科,江苏,214041 |
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| 摘 要： | 目的探讨雾化吸入布地奈德对轻中度支气管哮喘患者Th1/Th2细胞因子平衡的影响。方法49例轻中度支气管哮喘患者随机分为对照组(25例)和治疗组(24例)。两组均予吸氧、抗感染、静脉氨茶碱及对症治疗等。治疗组加用布地奈德混悬液氧气雾化吸入。分别采用ELISA法检测两组哮喘患者治疗前、治疗两周后及健康体检者外周血浆白细胞介素-5(inter-leuk in-5)和IL-12水平;同时测定两组哮喘患者治疗前后的FEV1。结果两组哮喘患者治疗前后血浆IL-5水平明显高于健康体检组,而IL-12水平则明显低于健康体检组,均P0.05;治疗后两哮喘组IL-5、IL-12水平与治疗前比较,均P0.01,治疗组与对照组治疗后比较IL-5、IL-12亦均差异显著;无论是治疗前还是治疗后,两组哮喘患者血浆IL-5与IL-12均呈明显的直线副相关。结论Th1/Th2的失衡与哮喘发病密切相关;布地奈德雾化吸入可通过调节Th1/Th2的平衡而治疗哮喘。
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| 关 键 词： | 支气管哮喘 布地奈德 雾化吸入 Th1／Th2细胞因子 白细胞介素-5 白细胞介素-12 |
The effect of inhale of budesonide suspension on the balance of Th1/Th2 cytokines in the treatment of mild-to-moderate persistent asthma |
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| ZUO Zhi-tong,CHEN Bao-hua,WANG Xu,ZHANG Cai-di,ZOU Xin-zhong,SHI Jian-ping.The effect of inhale of budesonide suspension on the balance of Th1/Th2 cytokines in the treatment of mild-to-moderate persistent asthma[J].Journal of Clinical Pulmonary Medicine,2010,15(2):177-178. |
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| Authors: | ZUO Zhi-tong CHEN Bao-hua WANG Xu ZHANG Cai-di ZOU Xin-zhong SHI Jian-ping |
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| Institution: | ZUO Zhi-tong, CHEN Bao-hua, WANG Xu, ZHANG Cai-di, ZOU Xin-zhong, SHI Jian- ping.( Department of Respiratory Medicine, the Third Hospital Affiliated to Nantong University, Jiangsu Wuxi 214041, China) |
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| Abstract: | Objective To investigate the effect of inhale budesonide suspension on the balance of Th1/Th2 cytokines in the treatment of mild-to-moderate persistent asthma.Methods 49 patients with mild-to-moderate persistent asthma were divided into two groups(the treatment group and the control group)at random.The two groups received inhale oxygen,anti-infection,intravenous aminophylline and symptom therapy,and the treatment group attached to inhale budesonide suspension with oxygen.All patients underwent plasm IL-5,IL... |
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| Keywords: | asthma budesonide inhale Th1/Th2 cytokines IL-5 IL-12 |
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