HBV血清学标记携带者家庭内传染性多因素分析

HBV血清学标记携带者的传染受许多因素的影响。本研究采用多因素分析方法,定量描述了各种类型HBV血清学标记携带者家庭内传染性及有关因素影响的大小。家中上次HBsAg携带与易感者HBsAg和HBeAg阳转呈正相关。家中上次抗-HBc携带与易感者抗-HBc阳转呈正相关,OR=5.98;但与抗-HBc滴度变化无显著联系。而家中上次抗-HBc携带,HBsAg与抗-HBc同时携带与易感者HBsAg和HBeAg阳转呈负相关。年龄与HBsAg阳转呈负相关;文化水平与易感者抗-HBs阳转亦呈负相关;手术史、注射史与乙肝续发感染正相关。多因素分析对阐明人群中大量HBV血清学标记携带者的动态变化有一定意义。

A Multivariate Analysis of Risk Factors Affecting Infectivity of HBV Serological Marker Carriers in Family

HBV transmission in family is influenced by many factors. The effect of different HBV serological markers and other risk factors on transmission of HBV within family could be quantified by multivariate analysis.
It was found that existence of HBsAg carriers was Positively associated with later aquiring HBsAg and HBeAg among susceptible contacts in the family. The existence of Anti-HBc carriers in family was Positively correlated with aquiring Anti-HBc of susceptible contacts, OR=5.98, however, it has no relationship with their titre variation of Anti-HBc. The existence of Anti-HBc carriers and both HBsAg and Anti-HBc combined carriers were negatively correlated with serum conversion to HBsAg and HBeAg of susceptible contacts.
Age was negatively associated with HBsAg conversion. Educational level was negatively associated with Anti-HBs conversion. Operations and injections were Positively associated with HBV serological markers conversion. Multivariate analysis is essentially helpful in evaluating dynamic variation of HBV serological marker carriers in Population.