Cerebral blood volume,blood flow,and oxygen metabolism in cerebral ischaemia and subarachnoid haemorrhage: An in-vivo study using positron emission tomography |
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| Authors: | W R W Martin MD F R CP R P Baker MD R L Grubb MD M E Raichle MD |
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| Institution: | (1) Department of Medicine, Health Sciences Centre Hospital, The University of British Columbia, Vancouver B.C., Canada;(2) Present address: Division of Neurology, Health Sciences Centre Hospital, University of British Columbia, V6T 1W5 Vancouver B.C., Canada;(3) Present address: Department of Neurology and Neurological Surgery, Washington University Medical School, 660 S. Euclid, 63110 St. Louis, MO, USA |
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| Abstract: | Summary A characteristic sequence of metabolic and haemodynamic changes has been shown to occur in the brain as cerebral perfusion pressure is reduced in experimental animals. Increased cerebral blood volume (CBV) occurs initially, followed by a fall in blood flow (CBF) and, finally, a fall in oxygen metabolism (CMRO2). By measuring CBV, CBF, and CMRO2 with positron emission tomography in patients with vasospasm associated with subarachnoid haemorrhage and in patients with arteriosclerotic occlusion or stenosis of extraparenchymal cerebral arteries, we have demonstrated the presence of similar changes distal to such lesions in man. These findings suggest the presence of a local decrease in perfusion pressure. This study demonstrates the utility of positron emission tomography in the assessment of cerebral circulation and metabolism in man. Measurements of regional CBV must be included for a complete assessment of the dynamics of the cerebral circulation.Presented at the Symposium on Cerebral Veins, Graz, Austria, 1982. |
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