Psychosis of epilepsy--an approach to a biological basis for postictal and interictal psychoses |
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| Authors: | M Sato |
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| Affiliation: | Department of Psychiatry, Tohoku University Medical School, Sendai, Japan. |
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| Abstract: | Postictal and interictal changes in behavior and the corresponded neurochemical data in the kindling model of epilepsy are reviewed briefly to explore a biological base for epileptic psychosis. Kindling can be a potent animal model to study this problem. A possible participation of both TRH and opioid system in prolonged postictal behavior disorder and of TRH, mesolimbic system and/or PI response to excitatory amino acid in interictal behavior disorder are discussed. A further experimental study is required to disclose the basic mechanism of epileptic psychosis. |
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