| 广枣总黄酮对豚鼠右心室乳头肌的影响 |
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| 引用本文： | 张莎莎,王玉华,爱民.广枣总黄酮对豚鼠右心室乳头肌的影响[J].中国药理学通报,2002,18(2):226-229. |
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| 作者姓名： | 张莎莎 王玉华 爱民 |
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| 作者单位： | 内蒙古医学院基础部药理学教研室,呼和浩特,010059 |
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| 摘 要： | 目的 研究广枣总黄酮 (TFC)心血管药理作用的机制。方法 将TFC作用于豚鼠右心室乳头肌 ,测定离体豚鼠右心室乳头肌的变化。结果 ①TFC使乳头肌的收缩力和收缩速率均减弱。②给予TFC时 ,CaCl2 的量 效曲线右移 ,并呈较好的量效关系。③TFC浓度为 30 4 μmol·L-1时可明显延长右心室乳头肌功能性不应期 (FRP) ,但对兴奋性无影响。结论 TFC可以浓度依赖性地阻滞细胞外Ca2 +进入细胞内 ,具有钙拮抗作用
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| 关 键 词： | 广枣 广枣总黄酮(TFC) 豚鼠 乳头肌 收缩力 功能性不应期(FRP) 兴奋性 |
| 文章编号： | 1001-1978(2002)02-0226-04 |
Effects of TFC on the right ventricle papillary muscles of guinea pig |
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| ZHANG Sha Sha,WANG Yu Hua,AI Min.Effects of TFC on the right ventricle papillary muscles of guinea pig[J].Chinese Pharmacological Bulletin,2002,18(2):226-229. |
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| Authors: | ZHANG Sha Sha WANG Yu Hua AI Min |
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| Abstract: | AIM To study the mechanism of effects about total flavones of choeropondias axillaris(TFC) to heart. METHODS The effects of TFC on contractility were investigated through acting on the guinea pig right ventricle papillary muscles. RESULTS ① TFC decreased both the contractility and contraction rate of papillary muscles. ②The quantity effect curve of CaCl 2 was shifted to right after giving TFC. ③TFC 30.4 μmol·L -1 prolonged remarkably the functional refractory period (FRP) of guinea pig right ventricle papillary muscles, but exerted no effect on excitability. CONCLUSION TFC can inhibit the Ca 2+ influx into cell in a concentration dependent manner. |
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| Keywords: | choeropondias axillaris total flavones of choeropondias axillaris(TFC) guinea pig papillary muscle contractility functional refractory period (FRP) excitability |
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