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Chronic monotherapy with rosuvastatin prevents progressive left ventricular dysfunction and remodeling in dogs with heart failure
Authors:Zacà Valerio  Rastogi Sharad  Imai Makoto  Wang Mengjun  Sharov Victor G  Jiang Alice  Goldstein Sidney  Sabbah Hani N
Affiliation:Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Health System, Detroit, Michigan, USA.
Abstract:
Keywords:BMSC, bone marrow-derived stem cell   CVD, cardiovascular disease   ECM, extracellular matrix   EDV, end-diastolic volume   EF, ejection fraction   EPC, endothelial progenitor cell   ESV, end-systolic volume   HD, high-dose   HF, heart failure   HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A   LD, low-dose   LV, left ventricular/ventricle   MCSA, myocyte cross-sectional area   MI, myocardial infarction   MMP, matrix metalloproteinase   ODD, oxygen diffusion distance   RSV, rosuvastatin   TNF, tumor necrosis factor   VFIF, volume fraction of interstitial fibrosis   VFRF, volume fraction of replacement fibrosis
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