Chronic monotherapy with rosuvastatin prevents progressive left ventricular dysfunction and remodeling in dogs with heart failure |
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Authors: | Zacà Valerio Rastogi Sharad Imai Makoto Wang Mengjun Sharov Victor G Jiang Alice Goldstein Sidney Sabbah Hani N |
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Affiliation: | Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Health System, Detroit, Michigan, USA. |
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Abstract: | |
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Keywords: | BMSC, bone marrow-derived stem cell CVD, cardiovascular disease ECM, extracellular matrix EDV, end-diastolic volume EF, ejection fraction EPC, endothelial progenitor cell ESV, end-systolic volume HD, high-dose HF, heart failure HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A LD, low-dose LV, left ventricular/ventricle MCSA, myocyte cross-sectional area MI, myocardial infarction MMP, matrix metalloproteinase ODD, oxygen diffusion distance RSV, rosuvastatin TNF, tumor necrosis factor VFIF, volume fraction of interstitial fibrosis VFRF, volume fraction of replacement fibrosis |
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