肾母细胞瘤术前化疗疗效分析

目的 探讨分析肾母细胞瘤术前化疗的优劣。方法 对35例手术治疗的肾母细胞瘤患的临床资料进行回顾性分析，其中27例患术前给予化疗。结果 化疗后肿瘤体积明显缩小17例，出现明显化疗药物毒副反应15例：术中死亡1例、术后切口延迟愈合4例、白细胞仍减少5例。结论 肾母细胞瘤术前化疗可有效地减少手术并发症的发生,合理的化疗方案的选择，积极的内科保守治疗可有效预防化疗毒副反应及并发症的发生。

Clinical effects of preoperative chemotherapy for Wilms tumor]

OBJECTIVE: To evaluate the effects of preoperative chemotherapy for Wilms' tumor. METHODS: Thirty-five surgically treated cases of Wilms tumor were retrospectively analyzed, 27 of which received preoperative chemotherapy. RESULTS: After chemotherapy, the tumor volume reduced obviously in 17 cases and adverse effects of the chemotherapeutic agents occurred in 15 cases. Subsequent operation was performed in all the patients, of whom 1 died during the operation, 4 had delayed healing of the incisions and 5 still had decreased leucocytes. CONCLUSIONS: Chemotherapy before the operation for Wilms tumor can effectively reduce the complications of the operation. Appropriate chemotherapy protocol and vigorous conservative drug therapy help prevent the occurrence of adverse effects and complications of the chemotherapy.