达立通颗粒治疗糖尿病胃轻瘫45例

目的：探讨达立通颗粒治疗糖尿病胃轻瘫（DGP）的临床疗效及胃动素、胃泌素及胃电图的影响。方法：将90例DGP患者随机按数字法分为对照组和观察组各45例。另设15例单纯糖尿病（DM）作为对照组。两组患者采用糖尿病常规治疗。对照组饭前服用盐酸伊托必利片，50 mg/次，3次/d；观察组饭前服用达立通颗粒，6 g/次，3次/d。两组疗程均为4周。采用放射免疫分析法测定治疗前后血浆胃动素和胃泌素水平；进行治疗前后胃电图检测；记录治疗前后主要症状、体征评分。结果：观察组总有效率为91.11%优于对照组的73.33%（P<0.05）；治疗前两组血浆胃动素和胃泌素水平均高于单纯DM组（P<0.01），治疗后观察组血浆胃动素和胃泌素水平低于对照组（P<0.01）；观察组胃电图餐前主功率、主频率均高于对照组，胃动过缓率低于对照组（P<0.01）；观察组胃电图餐后主功率、主频率均高于对照组，胃动过缓率低于对照组（P<0.01）；两组治疗后各主要症状、体征评分均治疗前下降（P<0.01），观察组治疗后各主要症状、体征评分均低于对照组（P<0.01）。结论：达立通颗粒能促进DGP患者胃蠕动、改善胃动力，减轻临床症状，还能调节胃肠激素，临床有一定的疗效。

Dalitong Granule in Treatment of Diabetic Gastroparesis with 45 Cases

Objective: Investigate Dalitong granule the clinical effect the influence to motilin, gastrin and electrogastrogram when be used in diabetic gastroparesis (DGP). Method: Ninety patients were randomly divided into control group (45 cases) and observation group (45 cases).And setting pure diabetes mellitus (DM) as control group (15 cases).Patients in the two groups were treated with conventional treatment. Patients in the control group were treated with itopride hydrochloride tablets, 50 mg/time, 3 times/d, taken before meals.Patients in the observation group were treated with Dalitong granule, 6 g/time, 3 times/day, taken before meals.the treatment courses of the two groups were both 12 weeks.Before and after treatment, determining the level of plasma motilin and gastrin by radioimmunoassay. Determining electrogastrogram, recordding main symptoms and sign grade before and after treatment. Result: The total effective rate of the observation group was 91.11% superior to 73.33% of the control group (P<0.05), Before treatment, the level of plasma molitin and gastrin of the two groups were both higher than those of the pure diabetes mellitus (DM) group (P<0.01), after treatment, the level of plasma molitin and gastrin of the observation group were lower than those of the control group (P<0.01), and the dominant power before meal, main frequency of the observation group were both higher than those of the control group, the rate of bradygastria was lower than that of the control group (P<0.01), after treatment, the main symptoms and sign score of the two groups both decreased (P<0.01), and for the observation group, the main symptoms and sign score were both lower than those of the control group (P<0.01). Conclusion: Dalitong granule for the DGP patients, it can promote peristole, improve motive power of the stomach, and there was regulation gastrointestinal hormone and a certain degree of clinical efficacy.