血小板增多、环氧化酶-2在老年胃癌中表达及预后

目的　研究血小板增多、环氧化酶 2 (COX 2 )表达与老年胃癌预后的关系。方法　回顾分析了 92例老年胃癌患者血小板增多、87例老年胃癌COX 2表达情况 ,并分析其与胃癌临床病理特征关系及预后影响。结果　胃癌患者血小板增多发生率为 2 8.2 6 % ,COX 2蛋白表达阳性率为 52 .5 % ,并且二者表达呈正相关 (P <0 .0 1 )。血小板增多、COX 2表达与肿瘤大小、浸润深度、淋巴结转移、TNM分期、血管癌栓密切相关 (P <0 .0 1 ) ,血小板增多、COX 2阳性表达与胃癌预后呈负相关。多因素分析表明 ,血小板增多是继TNM分期、淋巴结转移之后影响胃癌患者生存的独立预后因素。结论　血小板增多与COX 2表达密切相关 ,二者与胃癌生长、浸润关系密切 ,可作为估计老年胃癌预后的重要因素。

Poor prognosis associated with thrombocytosis and cyclooxygenase-2 (COX-2) expression in aged patients with gastric carcinoma

Objective To investigate the thrombocyto si s and cyclooxygenase-2 (COX-2) expression and their influence on clinicopathol ogical characteristics and the prognosis in aged patients with gastric carcinoma . Methods Platelet count increase in 92 cases with gast ric carcinoma and the expression of COX-2 in 87 patients with gastric carcinoma were reviewed, at the same time, their relations with clinicopathology and the ir influence on prognosis were analyzed. Results Thromb ocytosis was found in 26 patients (28.26%) and expression of COX-2 was observed in 52.5% of gastric carcinoma. A positive correlation was found between thrombo cytosis and COX-2 expression. The expression of COX-2 and thrombocytosis were related to the tumor size, depth, lymph node metastasis, vessel invasion and TNM stage (P<0.01). The prognosis of patients with thrombocytosis and express ion of COX-2 was poor. Multivariate analysis demonstrated that thrombocytosis was an independent prognostic factor after lymph node metastasis and TNM stage. Conclusions Thrombocytosis and expression of COX-2 in gastric carcinoma enhance the possibility of invasion and metastasis and implic ate a poor prognosis.