合并结核感染的支气管哮喘儿童临床治疗研究

目的观察结核感染对儿童支气管哮喘疗效的影响,为人工结核感染辅助治疗儿童哮喘提供科学依据。方法 32例有结核感染的支气管哮喘患儿作为观察组,27例无结核感染的哮喘患儿为对照组,两组均给予布地耐德福莫特罗粉吸入剂吸入治疗,剂量为80/4.5μg,早晚各吸1次。有哮喘急性发作时,加用沙丁胺醇（万托林）气雾剂,病情较重时加用强的松口服。观察组另外加用抗结核药物治疗。比较两组治疗效果。结果治疗3个月、6个月后万托林、强的松平均个人使用剂量观察组小于对照组,差异有统计学意义（P〈0.05）;呼吸道感染次数、急诊次数3个月后两组差异无统计学意义（P〉0.05）,6个月后,观察组明显少于对照组,差异有统计学意义（P〈0.05）,住院次数两组差异无统计学意义（P〉0.05）;两组用力肺活量（FVC）、一秒用力呼气容积（FEV1）、一秒率（FEV1/FVC）、用力呼气瞬间流速FEF25、FEF50、FEF753个月后均有增加,但差异无统计学意义（P〉0.05）,6个月后观察组增加明显好于对照组,差异有统计学意义（P〈0.05）。结论结核感染可以增加支气管哮喘患儿吸入糖皮质激素治疗的疗效,为人工结核感染辅助治疗儿童支气管哮喘提供科学依据。

Clinical analysis of the efficacy of 32 cases of the asthma children with tuberculosis infection

Objective The inrestigotior of impact of tuberculosis(TB) infection on the efficacy of inhaled glucocorticoids on children has provided the scientific evidence of TB infection for adjuvant treatment of asthma in children.Methods 32 cases of asthma children who concurrently infected TB were enrolled as the observation group,control group consisted of 27 cases of asthma children who tuberculin purified protein derivative (TB-PPD) skin test are negative.All the asthma children were treated with Budesonide and ...