Abnormal dexamethasone suppression test in primary obsessive-compulsive patients: A confirmatory report |
| |
Authors: | Jean A. Cottraux Martine Bouvard Bruno Claustrat Christian Juenet |
| |
Affiliation: | 1. Jean A. Cottraux, M.D., Ph.D., Martine Bouvard, M.A., and Christian Juenet, M.D., are in the Laboratoire de Psychologie Médicale, Neurological Hospital, 59, boulevard Pinel, 69003 Lyon, France;2. Bruno Claustrat, Ph.D., is in the Service de Radiopharmacie et Radioanalyse, Centre de Médicine Nucléire, Neucardiological Hospital, 59, boulevard Pinel, 69003 Lyon, France |
| |
Abstract: | The dexamethasone suppression test (DST) was administered after baseline cortisol measurements in 20 patients (10 males, 10 females) who met DSM-III criteria for obsessive-compulsive disorder (OCD). Six patients (30%) showed an abnormal escape from dexamethasone suppression. DST suppressors vs. DST nonsuppressors showed no differences in age, rate of secondary depressive disorders, or scores on the Hamilton Rating Scale for Depression, the Minnesota Multiphasic Personality Inventory D scale, or OCD rating scales. Surprisingly, there was a trend for suppressors to have a stringer family history of depressive disorders, and for nonsuppressors to include an excess of male subjects. Moreover, there was a significant correlation between levels of cortisol before and after DST. In five of six nonsuppressors, both depressive symptoms and obsessive- compulsive behaviors showed a diminution in response to antidepressant therapy combined, in one case, with intensive behavior therapy. The relationships between OCD and endogenous depression, as well as the specificity of the DST, are discussed. |
| |
Keywords: | Dexamethasone suppression test obsessive-compulsive disorders cortisol depression |
本文献已被 ScienceDirect 等数据库收录! |
|