孟鲁司特对咳嗽变异性哮喘患者Th1／Th2平衡的影响

目的探讨孟鲁司特对咳嗽变异性哮喘（CVA）患者Th1／Th2平衡的影响。方法将60例（CVA）患者随机分为对照组和治疗组各30例。对照组予以多索茶碱口服、布地耐德＋硫酸特布他林雾化吸入等治疗；治疗组在对照组基础上加用孟鲁司特10mg，睡前口服，两组均10天为一疗程。结果治疗一疗程后，治疗组显效率为76．7％、总有效率为100．0％，均明显高于对照组的43．3％、83．3％（均P〈0．05）。治疗前IFN-γ／IL-4比值。治疗组、对照组基本一致（P〉0．05）；治疗后IFN-γ／IL-4比值，治疗组明显高于对照组（P〈0．05）。结论孟鲁司特对CAV患者的Th1／Th2平衡有一定的调节作用，治疗CVA疗效确切。有一定的临床推广价值。

Effects of montelukast on Th1/Th2 balance in patients with cough variant asthma

OBJECTIVE To investigate effects of montelukast on Th1/Th2 balance in patients with cough variant asthma （CVA）. METHODS Sixty CVA patients were randomly divided into control group and treatment group, with 30 patients in each group. In control group, doxofylline were given orally, budesonide and terbutaline sulfate aerosol were inhaled; in treatment group, 10rag montelukast was added on the basis of the control group, taken orally at bedtime, 10 days as a course of treatment in both groups. RESULTS After one course of treat- ment, the response rate was 76.7 % and the total effective rate was 100.0 % in treatment group, both were significantly higher than those in control group （43.3%; 83.3% ）（P 〈 0.05）. IFN-γ/IL-4 ratios of treatment group and control group were basically the same before treatment （P 〉 0.05） ; IFN-γ/IL-4 ratio of treatment group was significantly higher than that of control group after treatment （P 〈 0.05）. CONCLUSION Montelukast plays a certain regulatory role on Th1/Th2 balance in CVA patients, shows a definite curative effect on the treatment of CVA, and has a certain clinical application value.