血浆B型利钠肽与心房纤颤关系的研究

目的研究心房纤颤患者血浆脑利钠肽（BNP）水平的变化及临床意义。方法用免疫荧光法测定18例阵发性心房纤颤患者、30例永久性心房纤颤患者和20例健康者（对照组）血浆BNP浓度作对比分析。结果血浆BNP水平在阵发性心房纤颤期间明显高于窦性心律时，当阵发性心房纤颤转为窦性心律时可降至正常水平。阵发性心房纤颤发作期间及永久性心房纤颤血浆BNP值明显高于对照组，差异有统计学意义（P〈0．01），而阵发性心房纤颤发作期间及永久性心房纤颤两者之间血浆BNP值善鼻无统计学煮义（P〉0．05）．结论心房纤颤可致血浆BNP值升高。

The research on the relationgship between the brain natriuretic peptide (BNP) and atrial fibrilation

Objective To study the changes of BNP of atrial f ibrilation and its clinical significance of BNP changes. Methods By using immunofluorescence,We can detect the plasma concentration of 18 paroxysmal atrial fibrilation patients, 30 perpetual atrial fibrilation patients and 20 healthy people （ control group）, at the same time we analyzed the difference of the three groups. Results The BNP in atrial fibrilation patients was obviously higher than the sinus rhythm people. When the atrial fibrilation returns m the sinus rhythm,the BNP also decreases to the normal level. Both the BNP of the paroxysmal atrial fibrilation patients and the perpetual atrial fibrilation patients were obviously higher than the control group, the differences had statistic significance （P 〈 0. 01 ）, however, the differences between the paroxysmal atrial fibrilation patients and the perpetual atrial fibrilation patients did＇ t have statistic significance. Conclusion Atrial fibrilation can result in the increase of BNP.