hMLH1在子宫内膜异位症中的表达与意义

目的：探讨错配修复基因1(hMLH1)的表达与子宫内膜异位症的关系。方法：采用免疫组织化学S-P法检测23例子宫内膜异位症组织和20例正常子宫内膜中hMLH1的表达。结果：内异症组hMLH1蛋白表达阳性率为65%（15例/23例），正常内膜组hMLH1蛋白表达阳性率为95%（19例/20例），差异有显著性(P<0.05)。内异症组hMLH1基因蛋白表达阴性及弱阳性率为69%（16例/23例）。正常内膜组中，hMLH1蛋白表达阴性及弱阳率为35%（7例/20例），差异有显著性(P<0.05)。结论： hMLH1基因的无表达或表达减弱是子宫内膜异位症发生的重要机制之一。

Exprewssion and significance of hMLH1 in endometriosis

Objective To study the correlation of the expression of human mismatches repair gene(hMLH1) with endometriosis. ***.Methods The protein expression of hMLH1 was analysed in 23 tissue of endometriosis and 20 tissue of normal endometrium by the immunohistochemistry SP method. Results The positive expression of hMLH1 in endometriosis was 65% (15 /23), The positive expression of hMLH1 in normal endometrium was 95%(19 cases/20 cases) .It was significantly different(P<0.05). The negative and low expression of hMLH1 in endometriosis was 69% (16 /23), The negative and low expression of hMLH1 in normal endometrium was 35%(7 cases/20 cases) . It was significantly different(P<0.05). Conclusions The negative or low expression of hMLH1 was one of the important mechanisms of endometriosis.